This comprehensive research report provides a detailed analysis of the Global Metabotropic Glutamate Receptor 4 (mGluR4) Market, encompassing its clinical development pipeline, investment landscape, and projected commercial status through 2036.
The mGluR4 market is a high-growth sector within neuropharmacology, primarily focused on Positive Allosteric Modulators (PAMs) designed to treat neurodegenerative and psychiatric disorders without the side effects of traditional dopaminergic therapies.
1. Market Overview
The global mGluR4 market is entering a pivotal phase as several lead compounds transition into advanced clinical trials. While the market was historically driven by research grants and venture capital, the shift toward commercialization for Parkinson’s Disease and Neurodevelopmental Disorders is expected to drive significant valuation increases.
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Base Year: 2025
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Forecast Period: 2026–2036
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Growth Driver: Rising prevalence of Parkinson’s Disease and the demand for non-dopaminergic symptomatic relief.
2. Expanded Key Players
The competitive landscape includes biotechnology firms specializing in Allosteric Modulation and major pharmaceutical companies through licensing agreements:
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Addex Therapeutics Ltd (Pioneer in allosteric modulation)
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Domain Therapeutics SA (Focus on GPCR targeting)
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Lundbeck A/S (Acquired Prexton Therapeutics and their mGluR4 assets)
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Merck KGaA (Significant R&D presence in glutamate receptors)
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Janssen Pharmaceuticals (Johnson & Johnson)
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Eli Lilly and Company
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Bristol Myers Squibb (BMS)
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AstraZeneca
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Bioasis Technologies Inc.
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Vanderbilt University (VICB) (Leading academic research partner)
3. Segment Analysis
By Product Type (Lead Compounds & Modulators)
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Foliglurax (PXT-02331): A lead candidate for Parkinson’s Disease Levodopa-Induced Dyskinesia (LID).
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ADX-88178: Noted for its potential in treating anxiety and neuroprotection.
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VU-0418506 / VU-0155041: Research-grade and clinical candidates emerging from academic-industry partnerships.
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JBPOS-0101: Emerging clinical candidate with potential across multiple CNS indications.
By Therapeutic Application
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Parkinson’s Disease (PD): The largest segment, focusing on reducing "Off" time and dyskinesia.
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Neurodevelopmental Disorders (Autism/Fragile X): Growing focus on modulating excitatory/inhibitory balance.
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Psychiatric Disorders: Including treatment-resistant depression and Generalized Anxiety Disorder (GAD).
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Other CNS Disorders: Epilepsy and neuropathic pain management.
By Phase of Development
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Pre-clinical Research: High volume of novel PAMs and NAMs.
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Clinical Phase I & II: Leading edge of market valuation.
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Late-stage Phase III: Future revenue drivers (expected post-2026).
4. Regional Analysis
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North America: The dominant region due to high R&D investment, concentrated CNS research hubs in the US, and favorable FDA "Fast Track" designations for orphan neurodegenerative diseases.
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Europe: A key hub for biotech innovation (Switzerland and France) and home to major players like Lundbeck and Merck KGaA.
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Asia-Pacific: Fastest growing region in terms of clinical trial sites and an aging population in Japan and China, driving the demand for PD therapeutics.
5. Porter’s Five Forces Analysis
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Bargaining Power of Buyers (Low): In the clinical stage, "buyers" are primarily pharmaceutical giants acquiring biotechs. Post-launch, the essential nature of CNS drugs limits buyer power.
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Bargaining Power of Suppliers (Moderate): Specialist CROs and high-purity chemical suppliers for GPCR screening are critical but relatively numerous.
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Threat of New Entrants (Low): High barriers to entry due to extreme R&D costs, complex intellectual property (IP) around allosteric sites, and stringent regulatory pathways.
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Threat of Substitutes (Moderate): Traditional L-Dopa treatments and emerging Deep Brain Stimulation (DBS) therapies represent indirect competition.
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Competitive Rivalry (High): Intense race among a few specialized firms to reach the first-in-class approval for mGluR4 PAMs.
6. SWOT Analysis
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Strengths: Highly selective targeting (PAMs) reduces the "ceiling effect" and side-effect profile compared to orthosteric agonists.
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Weaknesses: High failure rate in CNS clinical trials; complexity of mGluR4 signaling pathways.
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Opportunities: Expansion into orphan indications (e.g., Rett Syndrome); neuroprotective potential that could modify disease progression rather than just symptoms.
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Threats: Regulatory hurdles regarding long-term safety profiles of allosteric modulators.
7. Trend Analysis
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Allosteric Modulation over Agonism: The market is moving away from direct agonists toward "fine-tuning" receptors via PAMs, which preserve the natural spatial and temporal patterns of neurotransmission.
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Strategic M&A: Large-cap pharma companies are increasingly acquiring clinical-stage biotech startups rather than developing mGluR4 assets in-house.
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Biomarker Integration: Increasing use of PET imaging and CSF biomarkers in trials to prove target engagement.
8. Drivers & Challenges
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Drivers:
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Rising global incidence of neurodegenerative diseases.
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Failure of current dopaminergic drugs to treat non-motor symptoms of PD.
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Increasing funding for "G-Protein Coupled Receptor" (GPCR) research.
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Challenges:
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Crossing the Blood-Brain Barrier (BBB) effectively.
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Species-specific differences in mGluR4 expression making pre-clinical data difficult to translate to humans.
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9. Value Chain Analysis
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Discovery: High-throughput screening (HTS) of chemical libraries.
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Optimization: Lead optimization focusing on lipophilicity and BBB penetration.
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Clinical Trials: Phase I-III testing for safety and efficacy.
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Manufacturing: Specialized API production for CNS-active molecules.
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Distribution: Global specialty pharmacy and hospital networks for CNS medications.
10. Quick Recommendations for Stakeholders
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For Investors: Focus on companies with robust IP portfolios surrounding allosteric binding sites, as these offer the strongest protection against generics.
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For Biotech Firms: Prioritize Parkinson’s LID (Levodopa-Induced Dyskinesia) as the primary indication for faster orphan drug designation.
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For Research Institutions: Develop mGluR4-specific PET ligands to facilitate more accurate Phase I/II data, making assets more attractive for licensing.
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For Regulatory Affairs: Engage early with health authorities regarding the unique safety monitoring required for allosteric modulators compared to traditional agonists.
Table of Contents
Global Metabotropic Glutamate Receptor 4 Market Research Report 2026
1 Industry Overview of Metabotropic Glutamate Receptor 4
1.1 Definition and Specifications of Metabotropic Glutamate Receptor 4
1.1.1 Definition of Metabotropic Glutamate Receptor 4
1.1.2 Specifications of Metabotropic Glutamate Receptor 4
1.2 Classification of Metabotropic Glutamate Receptor 4
1.2.1 VU-0418506
1.2.2 ADX-88178
1.2.3 JBPOS-0101
1.2.4 PXT-2331
1.2.5 Others
1.3 Applications of Metabotropic Glutamate Receptor 4
1.3.1 Anxiety Disorders
1.3.2 Autism
1.3.3 Depression
1.3.4 Drug Addiction
1.3.5 Others
1.4 Market Segment by Regions
1.4.1 North America
1.4.2 Europe
1.4.3 China
1.4.4 Japan
1.4.5 Southeast Asia
1.4.6 India
2 Manufacturing Cost Structure Analysis of Metabotropic Glutamate Receptor 4
2.1 Raw Material and Suppliers
2.2 Manufacturing Cost Structure Analysis of Metabotropic Glutamate Receptor 4
2.3 Manufacturing Process Analysis of Metabotropic Glutamate Receptor 4
2.4 Industry Chain Structure of Metabotropic Glutamate Receptor 4
3 Technical Data and Manufacturing Plants Analysis of Metabotropic Glutamate Receptor 4
3.1 Capacity and Commercial Production Date of Global Metabotropic Glutamate Receptor 4 Major Manufacturers
3.2 Manufacturing Plants Distribution of Global Metabotropic Glutamate Receptor 4 Major Manufacturers
3.3 R&D Status and Technology Source of Global Metabotropic Glutamate Receptor 4 Major Manufacturers
3.4 Raw Materials Sources Analysis of Global Metabotropic Glutamate Receptor 4 Major Manufacturers
4 Global Metabotropic Glutamate Receptor 4 Overall Market Overview
4.1 E Overall Market Analysis
4.2 Capacity Analysis
4.2.1 E Global Metabotropic Glutamate Receptor 4 Capacity and Growth Rate Analysis
4.2.2 Metabotropic Glutamate Receptor 4 Capacity Analysis (Company Segment)
4.3 Sales Analysis
4.3.1 E Global Metabotropic Glutamate Receptor 4 Sales and Growth Rate Analysis
4.3.2 Metabotropic Glutamate Receptor 4 Sales Analysis (Company Segment)
4.4 Sales Price Analysis
4.4.1 E Global Metabotropic Glutamate Receptor 4 Sales Price
4.4.2 Metabotropic Glutamate Receptor 4 Sales Price Analysis (Company Segment)
5 Metabotropic Glutamate Receptor 4 Regional Market Analysis
5.1 North America Metabotropic Glutamate Receptor 4 Market Analysis
5.1.1 North America Metabotropic Glutamate Receptor 4 Market Overview
5.1.2 North America E Metabotropic Glutamate Receptor 4 Local Supply, Import, Export, Local Consumption Analysis
5.1.3 North America E Metabotropic Glutamate Receptor 4 Sales Price Analysis
5.1.4 North America Metabotropic Glutamate Receptor 4 Market Share Analysis
5.2 Europe Metabotropic Glutamate Receptor 4 Market Analysis
5.2.1 Europe Metabotropic Glutamate Receptor 4 Market Overview
5.2.2 Europe E Metabotropic Glutamate Receptor 4 Local Supply, Import, Export, Local Consumption Analysis
5.2.3 Europe E Metabotropic Glutamate Receptor 4 Sales Price Analysis
5.2.4 Europe Metabotropic Glutamate Receptor 4 Market Share Analysis
5.3 China Metabotropic Glutamate Receptor 4 Market Analysis
5.3.1 China Metabotropic Glutamate Receptor 4 Market Overview
5.3.2 China E Metabotropic Glutamate Receptor 4 Local Supply, Import, Export, Local Consumption Analysis
5.3.3 China E Metabotropic Glutamate Receptor 4 Sales Price Analysis
5.3.4 China Metabotropic Glutamate Receptor 4 Market Share Analysis
5.4 Japan Metabotropic Glutamate Receptor 4 Market Analysis
5.4.1 Japan Metabotropic Glutamate Receptor 4 Market Overview
5.4.2 Japan E Metabotropic Glutamate Receptor 4 Local Supply, Import, Export, Local Consumption Analysis
5.4.3 Japan E Metabotropic Glutamate Receptor 4 Sales Price Analysis
5.4.4 Japan Metabotropic Glutamate Receptor 4 Market Share Analysis
5.5 Southeast Asia Metabotropic Glutamate Receptor 4 Market Analysis
5.5.1 Southeast Asia Metabotropic Glutamate Receptor 4 Market Overview
5.5.2 Southeast Asia E Metabotropic Glutamate Receptor 4 Local Supply, Import, Export, Local Consumption Analysis
5.5.3 Southeast Asia E Metabotropic Glutamate Receptor 4 Sales Price Analysis
5.5.4 Southeast Asia Metabotropic Glutamate Receptor 4 Market Share Analysis
5.6 India Metabotropic Glutamate Receptor 4 Market Analysis
5.6.1 India Metabotropic Glutamate Receptor 4 Market Overview
5.6.2 India E Metabotropic Glutamate Receptor 4 Local Supply, Import, Export, Local Consumption Analysis
5.6.3 India E Metabotropic Glutamate Receptor 4 Sales Price Analysis
5.6.4 India Metabotropic Glutamate Receptor 4 Market Share Analysis
6 Global E Metabotropic Glutamate Receptor 4 Segment Market Analysis (by Type)
6.1 Global E Metabotropic Glutamate Receptor 4 Sales by Type
6.2 Different Types of Metabotropic Glutamate Receptor 4 Product Interview Price Analysis
6.3 Different Types of Metabotropic Glutamate Receptor 4 Product Driving Factors Analysis
6.3.1 VU-0418506 Growth Driving Factor Analysis
6.3.2 ADX-88178 Growth Driving Factor Analysis
6.3.3 JBPOS-0101 Growth Driving Factor Analysis
6.3.4 PXT-2331 Growth Driving Factor Analysis
6.3.5 Others Growth Driving Factor Analysis
7 Global E Metabotropic Glutamate Receptor 4 Segment Market Analysis (by Application)
7.1 Global E Metabotropic Glutamate Receptor 4 Consumption by Application
7.2 Different Application of Metabotropic Glutamate Receptor 4 Product Interview Price Analysis
7.3 Different Application of Metabotropic Glutamate Receptor 4 Product Driving Factors Analysis
7.3.1 Anxiety Disorders of Metabotropic Glutamate Receptor 4 Growth Driving Factor Analysis
7.3.2 Autism of Metabotropic Glutamate Receptor 4 Growth Driving Factor Analysis
7.3.3 Depression of Metabotropic Glutamate Receptor 4 Growth Driving Factor Analysis
7.3.4 Drug Addiction of Metabotropic Glutamate Receptor 4 Growth Driving Factor Analysis
7.3.5 Others of Metabotropic Glutamate Receptor 4 Growth Driving Factor Analysis
8 Major Manufacturers Analysis of Metabotropic Glutamate Receptor 4
8.1 Addex Therapeutics Ltd
8.1.1 Company Profile
8.1.2 Product Picture and Specifications
8.1.2.1 Product A
8.1.2.2 Product B
8.1.3 Addex Therapeutics Ltd Metabotropic Glutamate Receptor 4 Sales, Ex-factory Price, Revenue, Gross Margin Analysis
8.1.4 Addex Therapeutics Ltd Metabotropic Glutamate Receptor 4 Business Region Distribution Analysis
8.2 Domain Therapeutics SA
8.2.1 Company Profile
8.2.2 Product Picture and Specifications
8.2.2.1 Product A
8.2.2.2 Product B
8.2.3 Domain Therapeutics SA Metabotropic Glutamate Receptor 4 Sales, Ex-factory Price, Revenue, Gross Margin Analysis
8.2.4 Domain Therapeutics SA Metabotropic Glutamate Receptor 4 Business Region Distribution Analysis
8.3 Prexton Therapeutics SA
8.3.1 Company Profile
8.3.2 Product Picture and Specifications
8.3.2.1 Product A
8.3.2.2 Product B
8.3.3 Prexton Therapeutics SA Metabotropic Glutamate Receptor 4 Sales, Ex-factory Price, Revenue, Gross Margin Analysis
8.3.4 Prexton Therapeutics SA Metabotropic Glutamate Receptor 4 Business Region Distribution Analysis
9 Development Trend of Analysis of Metabotropic Glutamate Receptor 4 Market
9.1 Global Metabotropic Glutamate Receptor 4 Market Trend Analysis
9.1.1 Global Metabotropic Glutamate Receptor 4 Market Size (Volume and Value) Forecast
9.1.2 Global Metabotropic Glutamate Receptor 4 Sales Price Forecast
9.2 Metabotropic Glutamate Receptor 4 Regional Market Trend
9.2.1 North America Metabotropic Glutamate Receptor 4 Consumption Forecast
9.2.2 Europe Metabotropic Glutamate Receptor 4 Consumption Forecast
9.2.3 China Metabotropic Glutamate Receptor 4 Consumption Forecast
9.2.4 Japan Metabotropic Glutamate Receptor 4 Consumption Forecast
9.2.5 Southeast Asia Metabotropic Glutamate Receptor 4 Consumption Forecast
9.2.6 India Metabotropic Glutamate Receptor 4 Consumption Forecast
9.3 Metabotropic Glutamate Receptor 4 Market Trend (Product Type)
9.4 Metabotropic Glutamate Receptor 4 Market Trend (Application)
10 Metabotropic Glutamate Receptor 4 Marketing Type Analysis
10.1 Metabotropic Glutamate Receptor 4 Regional Marketing Type Analysis
10.2 Metabotropic Glutamate Receptor 4 International Trade Type Analysis
10.3 Traders or Distributors with Contact Information of Metabotropic Glutamate Receptor 4 by Region
10.4 Metabotropic Glutamate Receptor 4 Supply Chain Analysis
11 Consumers Analysis of Metabotropic Glutamate Receptor 4
11.1 Consumer 1 Analysis
11.2 Consumer 2 Analysis
11.3 Consumer 3 Analysis
11.4 Consumer 4 Analysis
12 Conclusion of the Global Metabotropic Glutamate Receptor 4 Market Professional Survey Report
Methodology
Analyst Introduction
Data Source
List of Tables and Figures
Figure Picture of Metabotropic Glutamate Receptor 4
Table Product Specifications of Metabotropic Glutamate Receptor 4
Table Classification of Metabotropic Glutamate Receptor 4
Figure Global Production Market Share of Metabotropic Glutamate Receptor 4 by Type in
Figure VU-0418506 Picture
Table Major Manufacturers of VU-0418506
Figure ADX-88178 Picture
Table Major Manufacturers of ADX-88178
Figure JBPOS-0101 Picture
Table Major Manufacturers of JBPOS-0101
Figure PXT-2331 Picture
Table Major Manufacturers of PXT-2331
Figure Others Picture
Table Major Manufacturers of Others
Table Applications of Metabotropic Glutamate Receptor 4
Figure Global Consumption Volume Market Share of Metabotropic Glutamate Receptor 4 by Application in
Figure Anxiety Disorders Examples
Table Major Consumers in Anxiety Disorders
Figure Autism Examples
Table Major Consumers in Autism
Figure Depression Examples
Table Major Consumers in Depression
Figure Drug Addiction Examples
Table Major Consumers in Drug Addiction
Figure Others Examples
Table Major Consumers in Others
Figure Market Share of Metabotropic Glutamate Receptor 4 by Regions
Figure North America Metabotropic Glutamate Receptor 4 Market Size (Million USD) (2013-2025)
Figure Europe Metabotropic Glutamate Receptor 4 Market Size (Million USD) (2013-2025)
Figure China Metabotropic Glutamate Receptor 4 Market Size (Million USD) (2013-2025)
Figure Japan Metabotropic Glutamate Receptor 4 Market Size (Million USD) (2013-2025)
Figure Southeast Asia Metabotropic Glutamate Receptor 4 Market Size (Million USD) (2013-2025)
Figure India Metabotropic Glutamate Receptor 4 Market Size (Million USD) (2013-2025)
Table Metabotropic Glutamate Receptor 4 Raw Material and Suppliers
Table Manufacturing Cost Structure Analysis of Metabotropic Glutamate Receptor 4 in
Figure Manufacturing Process Analysis of Metabotropic Glutamate Receptor 4
Figure Industry Chain Structure of Metabotropic Glutamate Receptor 4
Table Capacity and Commercial Production Date of Global Metabotropic Glutamate Receptor 4 Major Manufacturers
Table Manufacturing Plants Distribution of Global Metabotropic Glutamate Receptor 4 Major Manufacturers
Table R&D Status and Technology Source of Global Metabotropic Glutamate Receptor 4 Major Manufacturers
Table Raw Materials Sources Analysis of Global Metabotropic Glutamate Receptor 4 Major Manufacturers
Table Global Capacity, Sales , Price, Cost, Sales Revenue (M USD) and Gross Margin of Metabotropic Glutamate Receptor 4 E
Figure Global E Metabotropic Glutamate Receptor 4 Market Size (Volume) and Growth Rate
Figure Global E Metabotropic Glutamate Receptor 4 Market Size (Value) and Growth Rate
Table E Global Metabotropic Glutamate Receptor 4 Capacity and Growth Rate
Table Global Metabotropic Glutamate Receptor 4 Capacity (K Pcs) List (Company Segment)
Table E Global Metabotropic Glutamate Receptor 4 Sales (K Pcs) and Growth Rate
Table Global Metabotropic Glutamate Receptor 4 Sales (K Pcs) List (Company Segment)
Table E Global Metabotropic Glutamate Receptor 4 Sales Price (USD/Pcs)
Table Global Metabotropic Glutamate Receptor 4 Sales Price (USD/Pcs) List (Company Segment)
Figure North America Capacity Overview
Table North America Supply, Import, Export and Consumption (K Pcs) of Metabotropic Glutamate Receptor 4 E
Figure North America E Metabotropic Glutamate Receptor 4 Sales Price (USD/Pcs)
Figure North America Metabotropic Glutamate Receptor 4 Sales Market Share
Figure Europe Capacity Overview
Table Europe Supply, Import, Export and Consumption (K Pcs) of Metabotropic Glutamate Receptor 4 E
Figure Europe E Metabotropic Glutamate Receptor 4 Sales Price (USD/Pcs)
Figure Europe Metabotropic Glutamate Receptor 4 Sales Market Share
Figure China Capacity Overview
Table China Supply, Import, Export and Consumption (K Pcs) of Metabotropic Glutamate Receptor 4 E
Figure China E Metabotropic Glutamate Receptor 4 Sales Price (USD/Pcs)
Figure China Metabotropic Glutamate Receptor 4 Sales Market Share
Figure Japan Capacity Overview
Table Japan Supply, Import, Export and Consumption (K Pcs) of Metabotropic Glutamate Receptor 4 E
Figure Japan E Metabotropic Glutamate Receptor 4 Sales Price (USD/Pcs)
Figure Japan Metabotropic Glutamate Receptor 4 Sales Market Share
Figure Southeast Asia Capacity Overview
Table Southeast Asia Supply, Import, Export and Consumption (K Pcs) of Metabotropic Glutamate Receptor 4 E
Figure Southeast Asia E Metabotropic Glutamate Receptor 4 Sales Price (USD/Pcs)
Figure Southeast Asia Metabotropic Glutamate Receptor 4 Sales Market Share
Figure India Capacity Overview
Table India Supply, Import, Export and Consumption (K Pcs) of Metabotropic Glutamate Receptor 4 E
Figure India E Metabotropic Glutamate Receptor 4 Sales Price (USD/Pcs)
Figure India Metabotropic Glutamate Receptor 4 Sales Market Share
Table Global E Metabotropic Glutamate Receptor 4 Sales (K Pcs) by Type
Table Different Types Metabotropic Glutamate Receptor 4 Product Interview Price
Table Global E Metabotropic Glutamate Receptor 4 Sales (K Pcs) by Application
Table Different Application Metabotropic Glutamate Receptor 4 Product Interview Price
Table Addex Therapeutics Ltd Information List
Table Product Overview
Table Addex Therapeutics Ltd Metabotropic Glutamate Receptor 4 Revenue (Million USD), Sales (K Pcs), Ex-factory Price (USD/Pcs)
Figure Addex Therapeutics Ltd Metabotropic Glutamate Receptor 4 Business Region Distribution
Table Domain Therapeutics SA Information List
Table Product Overview
Table Domain Therapeutics SA Metabotropic Glutamate Receptor 4 Revenue (Million USD), Sales (K Pcs), Ex-factory Price (USD/Pcs)
Figure Domain Therapeutics SA Metabotropic Glutamate Receptor 4 Business Region Distribution
Table Prexton Therapeutics SA Information List
Table Product Overview
Table Prexton Therapeutics SA Metabotropic Glutamate Receptor 4 Revenue (Million USD), Sales (K Pcs), Ex-factory Price (USD/Pcs)
Figure Prexton Therapeutics SA Metabotropic Glutamate Receptor 4 Business Region Distribution
Figure Global Metabotropic Glutamate Receptor 4 Market Size (K Pcs) and Growth Rate Forecast
Figure Global Metabotropic Glutamate Receptor 4 Market Size (Million USD) and Growth Rate Forecast
Figure Global Metabotropic Glutamate Receptor 4 Sales Price (USD/Pcs) Forecast
Figure North America Metabotropic Glutamate Receptor 4 Consumption Volume (K Pcs) and Growth Rate Forecast
Figure China Metabotropic Glutamate Receptor 4 Consumption Volume (K Pcs) and Growth Rate Forecast
Figure Europe Metabotropic Glutamate Receptor 4 Consumption Volume (K Pcs) and Growth Rate Forecast
Figure Southeast Asia Metabotropic Glutamate Receptor 4 Consumption Volume (K Pcs) and Growth Rate Forecast
Figure Japan Metabotropic Glutamate Receptor 4 Consumption Volume (K Pcs) and Growth Rate Forecast
Figure India Metabotropic Glutamate Receptor 4 Consumption Volume (K Pcs) and Growth Rate Forecast
Table Global Sales Volume (K Pcs) of Metabotropic Glutamate Receptor 4 by Type
Table Global Consumption Volume (K Pcs) of Metabotropic Glutamate Receptor 4 by Application
Table Traders or Distributors with Contact Information of Metabotropic Glutamate Receptor 4 by Region
Expanded Key Players
The competitive landscape includes biotechnology firms specializing in Allosteric Modulation and major pharmaceutical companies through licensing agreements:
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Addex Therapeutics Ltd (Pioneer in allosteric modulation)
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Domain Therapeutics SA (Focus on GPCR targeting)
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Lundbeck A/S (Acquired Prexton Therapeutics and their mGluR4 assets)
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Merck KGaA (Significant R&D presence in glutamate receptors)
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Janssen Pharmaceuticals (Johnson & Johnson)
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Eli Lilly and Company
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Bristol Myers Squibb (BMS)
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AstraZeneca
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Bioasis Technologies Inc.
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Vanderbilt University (VICB) (Leading academic research partner)
3. Segment Analysis
By Product Type (Lead Compounds & Modulators)
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Foliglurax (PXT-02331): A lead candidate for Parkinson’s Disease Levodopa-Induced Dyskinesia (LID).
-
ADX-88178: Noted for its potential in treating anxiety and neuroprotection.
-
VU-0418506 / VU-0155041: Research-grade and clinical candidates emerging from academic-industry partnerships.
-
JBPOS-0101: Emerging clinical candidate with potential across multiple CNS indications.
By Therapeutic Application
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Parkinson’s Disease (PD): The largest segment, focusing on reducing "Off" time and dyskinesia.
-
Neurodevelopmental Disorders (Autism/Fragile X): Growing focus on modulating excitatory/inhibitory balance.
-
Psychiatric Disorders: Including treatment-resistant depression and Generalized Anxiety Disorder (GAD).
-
Other CNS Disorders: Epilepsy and neuropathic pain management.
By Phase of Development
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Pre-clinical Research: High volume of novel PAMs and NAMs.
-
Clinical Phase I & II: Leading edge of market valuation.
-
Late-stage Phase III: Future revenue drivers (expected post-2026).
