Comprehensive Market Analysis Report: Global Premenstrual Syndrome (PMS) & Premenstrual Dysphoric Disorder (PMDD) Therapeutics Market (2026-2036)
1. Executive Summary
The global Premenstrual Syndrome (PMS) and Premenstrual Dysphoric Disorder (PMDD) therapeutics market addresses a significant, yet historically under-prioritized, area of women's health. Characterized by a complex interplay of physical and psychological symptoms, the treatment landscape is evolving from generic symptomatic relief toward targeted, neuroendocrine-based therapies. This report provides a refined analysis of the market status and forecast from 2026 to 2036, evaluating market size, key innovators, therapeutic segmentation, and regional dynamics. The market is poised for substantial growth, driven by increasing disease recognition, de-stigmatization, and the anticipated approval of novel, mechanism-specific pharmaceuticals.
2. Market Overview
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Market Valuation: The global PMS/PMDD therapeutics market is projected to grow robustly from 2026 to 2036, reaching a significant market value by the end of the forecast period, supported by a healthy Compound Annual Growth Rate (CAGR) upon successful market entry of novel agents.
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Base Year: 2025
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Forecast Period: 2026 - 2036
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Key Drivers: Rising awareness and clinical diagnosis of PMDD, growing advocacy for women's health, strong unmet need for effective and well-tolerated treatments, and a maturing pipeline of targeted neurosteroid modulators.
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Primary Challenges: Historical reliance on off-label and generic treatments, difficulty in objectively measuring symptom improvement in clinical trials, potential payer perception as a "lifestyle" condition, and the cyclical nature of treatment affecting adherence and commercial models.
3. Key Market Players
The competitive landscape features specialized biotech companies pioneering novel mechanisms, alongside large pharma with established CNS and women's health portfolios.
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Pipeline Innovators & Specialized Biotech:
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Asarina Pharma AB: Developer of sepranolone (ISO-1), a selective GABA-A modulating steroid antagonist (SAMSA) targeting PMDD.
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Marinus Pharmaceuticals, Inc.: Developer of ganaxolone, a neuroactive steroid GABA-A receptor positive allosteric modulator, with potential in PMDD and other CNS disorders.
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Fabre-Kramer Pharmaceuticals: Developer of paroxetine mesylate, a low-dose SSRI specifically approved for PMDD in some regions.
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Pherin Pharmaceuticals Inc.: Early-stage research on pheromone-based therapeutics.
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Large Pharmaceutical Companies with Relevant Portfolios:
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Pfizer Inc. (Historical and ongoing women's health and CNS research).
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GlaxoSmithKline plc (GSK) (Holder of paroxetine license; broad CNS portfolio).
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Eli Lilly and Company (Major player in neuroscience).
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Bayer AG (Strong presence in women's health, though historically focused on contraception/fertility).
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Sumitomo Pharma Co., Ltd. (Through its acquisition of Myovant Sciences, with expertise in endocrine therapies).
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4. Market Segmentation Analysis
4.1 By Drug Class & Mechanism of Action
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Selective Serotonin Reuptake Inhibitors (SSRIs): First-line pharmacological treatment for PMDD (e.g., fluoxetine, sertraline, paroxetine). Can be used continuously or luteal-phase only.
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Neurosteroid & GABA-Targeted Therapies (Novel/High-Growth Segment):
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GABA-A Receptor Modulators: Sepranolone (antagonist) and ganaxolone (PAM) - target allopregnanolone-driven mood symptoms.
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*5α-Reductase Inhibitors:* E.g., dutasteride - inhibits conversion of progesterone to allopregnanolone; investigational for PMDD.
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Hormonal Suppression Therapies: Includes combined oral contraceptives (COCs), particularly those containing drospirenone, and GnRH agonists (e.g., leuprolide) for severe cases.
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Symptomatic Relief & Adjuncts: Includes analgesics (NSAIDs), diuretics (spironolactone), and herbal/nutraceutical supplements (Vitex agnus-castus, calcium).
4.2 By Disorder Severity & Indication
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Premenstrual Dysphoric Disorder (PMDD): The primary target for novel prescription therapies due to its severity and clear diagnostic criteria (DSM-5). Represents the high-value segment.
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Moderate-to-Severe PMS: Larger patient population, often managed with OTC products, supplements, and lifestyle interventions, but a potential market for new Rx options.
4.3 By Treatment Regimen
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Continuous Daily Dosing: Standard for SSRIs and hormonal contraceptives.
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Intermittent (Luteal Phase) Dosing: Unique to PMS/PMDD. Involves taking medication only during the 14-day period before menstruation. A key differentiator for novel agents.
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As-Needed Symptomatic Relief: For physical symptoms like pain and bloating.
5. Regional Analysis
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North America: Largest and most advanced market, driven by high awareness, established diagnosis of PMDD, favorable regulatory pathways (FDA), and strong patient advocacy. The U.S. is the dominant country.
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Europe: Strong second market with growing recognition of PMDD. Growth is influenced by varying levels of awareness and reimbursement policies across EU member states.
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Asia-Pacific: Fastest-growing potential market over the forecast period. Growth is fueled by rapidly increasing awareness, improving access to women's healthcare, and large patient populations in countries like Japan, China, and India.
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Latin America, Middle East & Africa: Emerging markets where growth is tied to improving women's health education, economic development, and gradual reduction of social stigma surrounding menstrual health.
6. Porter’s Five Forces Analysis
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Threat of New Entrants: Moderate. Scientific understanding of neurosteroid mechanisms is attracting new biotech entrants. Barriers include conducting complex trials with subjective endpoints and navigating a market accustomed to cheap generics.
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Bargaining Power of Suppliers: Low for standard API. Moderate for specialized CROs experienced in designing women's health trials with patient-reported outcomes (PROs).
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Bargaining Power of Buyers: High. Includes patients (cost-sensitive), physicians accustomed to prescribing generics, and payers who may question the need for premium-priced drugs over existing cheap alternatives.
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Threat of Substitutes: Very High. Includes a wide array of OTC pain relievers, herbal supplements, lifestyle/dietary changes, generic SSRIs, and hormonal contraceptives.
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Industry Rivalry: Currently low among novel agents but set to increase. Initial competition is against the standard of care (generic SSRIs/COCs). Future rivalry will be based on efficacy, safety, dosing convenience, and speed of onset.
7. SWOT Analysis
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Strengths: Large, underserved patient population, strong biological rationale for new targets (GABA/neurosteroids), high potential for premium pricing if superior efficacy is proven, growing social momentum.
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Weaknesses: Subjective and variable symptomology complicating clinical trials, stigma leading to under-diagnosis, and reimbursement challenges for chronic, cyclical conditions.
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Opportunities: Being first-to-market with a novel, non-SSRI, non-hormonal mechanism for PMDD, digital therapeutics for tracking and adjunctive care, and expansion into related conditions (postpartum depression, perimenopause).
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Threats: Difficulty in demonstrating sufficient differentiation from generic SSRIs to justify cost, potential for low diagnosis and treatment rates in key growth markets, and safety concerns with novel CNS agents.
8. Trend Analysis
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Shift Toward Targeted Neuroendocrine Therapies: Moving beyond serotonin modulation to direct targeting of the GABAergic system and allopregnanolone fluctuations implicated in PMDD.
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Precision Medicine & Biomarker Exploration: Research into genetic, hormonal, or neuroimaging biomarkers to identify patient subgroups most responsive to specific therapies.
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Integration of Digital Health Tools: Use of mobile apps for daily symptom tracking, cycle prediction, and medication adherence, becoming integral to clinical trial design and patient management.
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Holistic Treatment Paradigms: Increasing recognition of the need for integrated care combining pharmacological, nutritional, psychological, and lifestyle interventions.
9. Market Drivers & Challenges
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Drivers:
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Increasing medical and public recognition of PMDD as a legitimate, severe neuroendocrine disorder.
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Strong advocacy from women's health organizations and patient communities.
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Successful clinical proof-of-concept for novel neurosteroid-targeting agents.
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Growing investment in women's health biotech and venture capital.
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Challenges:
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Designing clinical trials that reliably capture the cyclical, patient-reported nature of symptom improvement.
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Achieving market penetration against deeply entrenched, low-cost generic alternatives.
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Educating a broad base of healthcare providers (PCPs, GYNs, psychiatrists) on new diagnostic criteria and treatment options.
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Securing favorable reimbursement for chronic, intermittent therapies.
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10. Value Chain Analysis
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Basic Research & Target Identification: Neuroendocrinology research into the role of allopregnanolone, GABA, and serotonin in the menstrual cycle.
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Drug Discovery & Preclinical: Development of selective GABA-A modulators and other neuroactive compounds.
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Clinical Development: Trials require validated daily symptom diaries (e.g., DRSP) over multiple menstrual cycles, placebo lead-ins, and careful patient phenotyping.
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Regulatory & Market Access: Requires demonstrating a clinically meaningful improvement in patient-reported outcomes. Must engage payers early to establish the economic and humanistic burden of PMDD.
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Manufacturing: Standard synthesis for small molecules; may be more complex for certain neurosteroids.
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Commercialization & Education: Requires targeted campaigns to obstetrician/gynecologists, psychiatrists, and primary care physicians. Direct-to-patient education to raise awareness and reduce stigma is crucial.
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Patient Support & Adherence Programs: Essential for supporting intermittent dosing regimens and managing a chronic, cyclical condition.
11. Strategic Recommendations for Stakeholders
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For Pharmaceutical Companies: Invest in high-quality, well-designed Phase 3 trials that unequivocally demonstrate superiority or a unique benefit over generic SSRIs. Develop comprehensive disease awareness campaigns for both HCPs and patients to grow the diagnosed population. Consider value-based pricing and innovative access models.
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For Investors: Focus on companies with strong, clinically-validated mechanisms distinct from SSRIs, experienced management in CNS/women's health, and robust intellectual property. Proof-of-concept data showing rapid and significant symptom relief is key.
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For Healthcare Providers: Adopt and utilize standardized diagnostic tools (e.g., DSM-5 criteria, daily symptom charts) to properly identify PMDD patients. Stay informed on emerging neuroendocrine treatments to expand therapeutic options beyond SSRIs.
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For Payers & Policymakers: Recognize the significant functional and economic burden of severe PMDD. Develop reimbursement models that account for the intermittent dosing of effective therapies and their potential to improve productivity and quality of life.
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For Patients & Advocacy Groups: Continue to advocate for increased research funding and destigmatization. Participate in clinical trials to accelerate new treatment options. Utilize digital tools for accurate symptom tracking to improve dialogue with healthcare providers.
Table of Contents
Global Premenstrual Syndrome Medicine Market Research Report 2026
1 Industry Overview of Premenstrual Syndrome Medicine
1.1 Definition and Specifications of Premenstrual Syndrome Medicine
1.1.1 Definition of Premenstrual Syndrome Medicine
1.1.2 Specifications of Premenstrual Syndrome Medicine
1.2 Classification of Premenstrual Syndrome Medicine
1.2.1 PH-80PMD
1.2.2 Estrogen
1.2.3 Progesterone
1.2.4 Others
1.3 Applications of Premenstrual Syndrome Medicine
1.3.1 Home Care
1.3.2 Hospital
1.3.3 Clinic
1.4 Market Segment by Regions
1.4.1 North America
1.4.2 Europe
1.4.3 China
1.4.4 Japan
1.4.5 Southeast Asia
1.4.6 India
2 Manufacturing Cost Structure Analysis of Premenstrual Syndrome Medicine
2.1 Raw Material and Suppliers
2.2 Manufacturing Cost Structure Analysis of Premenstrual Syndrome Medicine
2.3 Manufacturing Process Analysis of Premenstrual Syndrome Medicine
2.4 Industry Chain Structure of Premenstrual Syndrome Medicine
3 Technical Data and Manufacturing Plants Analysis of Premenstrual Syndrome Medicine
3.1 Capacity and Commercial Production Date of Global Premenstrual Syndrome Medicine Major Manufacturers
3.2 Manufacturing Plants Distribution of Global Premenstrual Syndrome Medicine Major Manufacturers
3.3 R&D Status and Technology Source of Global Premenstrual Syndrome Medicine Major Manufacturers
3.4 Raw Materials Sources Analysis of Global Premenstrual Syndrome Medicine Major Manufacturers
4 Global Premenstrual Syndrome Medicine Overall Market Overview
4.1 E Overall Market Analysis
4.2 Capacity Analysis
4.2.1 E Global Premenstrual Syndrome Medicine Capacity and Growth Rate Analysis
4.2.2 Premenstrual Syndrome Medicine Capacity Analysis (Company Segment)
4.3 Sales Analysis
4.3.1 E Global Premenstrual Syndrome Medicine Sales and Growth Rate Analysis
4.3.2 Premenstrual Syndrome Medicine Sales Analysis (Company Segment)
4.4 Sales Price Analysis
4.4.1 E Global Premenstrual Syndrome Medicine Sales Price
4.4.2 Premenstrual Syndrome Medicine Sales Price Analysis (Company Segment)
5 Premenstrual Syndrome Medicine Regional Market Analysis
5.1 North America Premenstrual Syndrome Medicine Market Analysis
5.1.1 North America Premenstrual Syndrome Medicine Market Overview
5.1.2 North America E Premenstrual Syndrome Medicine Local Supply, Import, Export, Local Consumption Analysis
5.1.3 North America E Premenstrual Syndrome Medicine Sales Price Analysis
5.1.4 North America Premenstrual Syndrome Medicine Market Share Analysis
5.2 Europe Premenstrual Syndrome Medicine Market Analysis
5.2.1 Europe Premenstrual Syndrome Medicine Market Overview
5.2.2 Europe E Premenstrual Syndrome Medicine Local Supply, Import, Export, Local Consumption Analysis
5.2.3 Europe E Premenstrual Syndrome Medicine Sales Price Analysis
5.2.4 Europe Premenstrual Syndrome Medicine Market Share Analysis
5.3 China Premenstrual Syndrome Medicine Market Analysis
5.3.1 China Premenstrual Syndrome Medicine Market Overview
5.3.2 China E Premenstrual Syndrome Medicine Local Supply, Import, Export, Local Consumption Analysis
5.3.3 China E Premenstrual Syndrome Medicine Sales Price Analysis
5.3.4 China Premenstrual Syndrome Medicine Market Share Analysis
5.4 Japan Premenstrual Syndrome Medicine Market Analysis
5.4.1 Japan Premenstrual Syndrome Medicine Market Overview
5.4.2 Japan E Premenstrual Syndrome Medicine Local Supply, Import, Export, Local Consumption Analysis
5.4.3 Japan E Premenstrual Syndrome Medicine Sales Price Analysis
5.4.4 Japan Premenstrual Syndrome Medicine Market Share Analysis
5.5 Southeast Asia Premenstrual Syndrome Medicine Market Analysis
5.5.1 Southeast Asia Premenstrual Syndrome Medicine Market Overview
5.5.2 Southeast Asia E Premenstrual Syndrome Medicine Local Supply, Import, Export, Local Consumption Analysis
5.5.3 Southeast Asia E Premenstrual Syndrome Medicine Sales Price Analysis
5.5.4 Southeast Asia Premenstrual Syndrome Medicine Market Share Analysis
5.6 India Premenstrual Syndrome Medicine Market Analysis
5.6.1 India Premenstrual Syndrome Medicine Market Overview
5.6.2 India E Premenstrual Syndrome Medicine Local Supply, Import, Export, Local Consumption Analysis
5.6.3 India E Premenstrual Syndrome Medicine Sales Price Analysis
5.6.4 India Premenstrual Syndrome Medicine Market Share Analysis
6 Global E Premenstrual Syndrome Medicine Segment Market Analysis (by Type)
6.1 Global E Premenstrual Syndrome Medicine Sales by Type
6.2 Different Types of Premenstrual Syndrome Medicine Product Interview Price Analysis
6.3 Different Types of Premenstrual Syndrome Medicine Product Driving Factors Analysis
6.3.1 PH-80PMD Growth Driving Factor Analysis
6.3.2 Estrogen Growth Driving Factor Analysis
6.3.3 Progesterone Growth Driving Factor Analysis
6.3.4 Others Growth Driving Factor Analysis
7 Global E Premenstrual Syndrome Medicine Segment Market Analysis (by Application)
7.1 Global E Premenstrual Syndrome Medicine Consumption by Application
7.2 Different Application of Premenstrual Syndrome Medicine Product Interview Price Analysis
7.3 Different Application of Premenstrual Syndrome Medicine Product Driving Factors Analysis
7.3.1 Home Care of Premenstrual Syndrome Medicine Growth Driving Factor Analysis
7.3.2 Hospital of Premenstrual Syndrome Medicine Growth Driving Factor Analysis
7.3.3 Clinic of Premenstrual Syndrome Medicine Growth Driving Factor Analysis
8 Major Manufacturers Analysis of Premenstrual Syndrome Medicine
8.1 Asarina Pharma AB
8.1.1 Company Profile
8.1.2 Product Picture and Specifications
8.1.2.1 Product A
8.1.2.2 Product B
8.1.3 Asarina Pharma AB Premenstrual Syndrome Medicine Sales, Ex-factory Price, Revenue, Gross Margin Analysis
8.1.4 Asarina Pharma AB Premenstrual Syndrome Medicine Business Region Distribution Analysis
8.2 Pherin Pharmaceuticals Inc
8.2.1 Company Profile
8.2.2 Product Picture and Specifications
8.2.2.1 Product A
8.2.2.2 Product B
8.2.3 Pherin Pharmaceuticals Inc Premenstrual Syndrome Medicine Sales, Ex-factory Price, Revenue, Gross Margin Analysis
8.2.4 Pherin Pharmaceuticals Inc Premenstrual Syndrome Medicine Business Region Distribution Analysis
9 Development Trend of Analysis of Premenstrual Syndrome Medicine Market
9.1 Global Premenstrual Syndrome Medicine Market Trend Analysis
9.1.1 Global Premenstrual Syndrome Medicine Market Size (Volume and Value) Forecast
9.1.2 Global Premenstrual Syndrome Medicine Sales Price Forecast
9.2 Premenstrual Syndrome Medicine Regional Market Trend
9.2.1 North America Premenstrual Syndrome Medicine Consumption Forecast
9.2.2 Europe Premenstrual Syndrome Medicine Consumption Forecast
9.2.3 China Premenstrual Syndrome Medicine Consumption Forecast
9.2.4 Japan Premenstrual Syndrome Medicine Consumption Forecast
9.2.5 Southeast Asia Premenstrual Syndrome Medicine Consumption Forecast
9.2.6 India Premenstrual Syndrome Medicine Consumption Forecast
9.3 Premenstrual Syndrome Medicine Market Trend (Product Type)
9.4 Premenstrual Syndrome Medicine Market Trend (Application)
10 Premenstrual Syndrome Medicine Marketing Type Analysis
10.1 Premenstrual Syndrome Medicine Regional Marketing Type Analysis
10.2 Premenstrual Syndrome Medicine International Trade Type Analysis
10.3 Traders or Distributors with Contact Information of Premenstrual Syndrome Medicine by Region
10.4 Premenstrual Syndrome Medicine Supply Chain Analysis
11 Consumers Analysis of Premenstrual Syndrome Medicine
11.1 Consumer 1 Analysis
11.2 Consumer 2 Analysis
11.3 Consumer 3 Analysis
11.4 Consumer 4 Analysis
12 Conclusion of the Global Premenstrual Syndrome Medicine Market Professional Survey Report
Methodology
Analyst Introduction
Data Source
List of Tables and Figures
Figure Picture of Premenstrual Syndrome Medicine
Table Product Specifications of Premenstrual Syndrome Medicine
Table Classification of Premenstrual Syndrome Medicine
Figure Global Production Market Share of Premenstrual Syndrome Medicine by Type in
Figure PH-80PMD Picture
Table Major Manufacturers of PH-80PMD
Figure Estrogen Picture
Table Major Manufacturers of Estrogen
Figure Progesterone Picture
Table Major Manufacturers of Progesterone
Figure Others Picture
Table Major Manufacturers of Others
Table Applications of Premenstrual Syndrome Medicine
Figure Global Consumption Volume Market Share of Premenstrual Syndrome Medicine by Application in
Figure Home Care Examples
Table Major Consumers in Home Care
Figure Hospital Examples
Table Major Consumers in Hospital
Figure Clinic Examples
Table Major Consumers in Clinic
Figure Market Share of Premenstrual Syndrome Medicine by Regions
Figure North America Premenstrual Syndrome Medicine Market Size (Million USD) (2013-2025)
Figure Europe Premenstrual Syndrome Medicine Market Size (Million USD) (2013-2025)
Figure China Premenstrual Syndrome Medicine Market Size (Million USD) (2013-2025)
Figure Japan Premenstrual Syndrome Medicine Market Size (Million USD) (2013-2025)
Figure Southeast Asia Premenstrual Syndrome Medicine Market Size (Million USD) (2013-2025)
Figure India Premenstrual Syndrome Medicine Market Size (Million USD) (2013-2025)
Table Premenstrual Syndrome Medicine Raw Material and Suppliers
Table Manufacturing Cost Structure Analysis of Premenstrual Syndrome Medicine in
Figure Manufacturing Process Analysis of Premenstrual Syndrome Medicine
Figure Industry Chain Structure of Premenstrual Syndrome Medicine
Table Capacity and Commercial Production Date of Global Premenstrual Syndrome Medicine Major Manufacturers
Table Manufacturing Plants Distribution of Global Premenstrual Syndrome Medicine Major Manufacturers
Table R&D Status and Technology Source of Global Premenstrual Syndrome Medicine Major Manufacturers
Table Raw Materials Sources Analysis of Global Premenstrual Syndrome Medicine Major Manufacturers
Table Global Capacity, Sales , Price, Cost, Sales Revenue (M USD) and Gross Margin of Premenstrual Syndrome Medicine E
Figure Global E Premenstrual Syndrome Medicine Market Size (Volume) and Growth Rate
Figure Global E Premenstrual Syndrome Medicine Market Size (Value) and Growth Rate
Table E Global Premenstrual Syndrome Medicine Capacity and Growth Rate
Table Global Premenstrual Syndrome Medicine Capacity (K Pcs) List (Company Segment)
Table E Global Premenstrual Syndrome Medicine Sales (K Pcs) and Growth Rate
Table Global Premenstrual Syndrome Medicine Sales (K Pcs) List (Company Segment)
Table E Global Premenstrual Syndrome Medicine Sales Price (USD/Pcs)
Table Global Premenstrual Syndrome Medicine Sales Price (USD/Pcs) List (Company Segment)
Figure North America Capacity Overview
Table North America Supply, Import, Export and Consumption (K Pcs) of Premenstrual Syndrome Medicine E
Figure North America E Premenstrual Syndrome Medicine Sales Price (USD/Pcs)
Figure North America Premenstrual Syndrome Medicine Sales Market Share
Figure Europe Capacity Overview
Table Europe Supply, Import, Export and Consumption (K Pcs) of Premenstrual Syndrome Medicine E
Figure Europe E Premenstrual Syndrome Medicine Sales Price (USD/Pcs)
Figure Europe Premenstrual Syndrome Medicine Sales Market Share
Figure China Capacity Overview
Table China Supply, Import, Export and Consumption (K Pcs) of Premenstrual Syndrome Medicine E
Figure China E Premenstrual Syndrome Medicine Sales Price (USD/Pcs)
Figure China Premenstrual Syndrome Medicine Sales Market Share
Figure Japan Capacity Overview
Table Japan Supply, Import, Export and Consumption (K Pcs) of Premenstrual Syndrome Medicine E
Figure Japan E Premenstrual Syndrome Medicine Sales Price (USD/Pcs)
Figure Japan Premenstrual Syndrome Medicine Sales Market Share
Figure Southeast Asia Capacity Overview
Table Southeast Asia Supply, Import, Export and Consumption (K Pcs) of Premenstrual Syndrome Medicine E
Figure Southeast Asia E Premenstrual Syndrome Medicine Sales Price (USD/Pcs)
Figure Southeast Asia Premenstrual Syndrome Medicine Sales Market Share
Figure India Capacity Overview
Table India Supply, Import, Export and Consumption (K Pcs) of Premenstrual Syndrome Medicine E
Figure India E Premenstrual Syndrome Medicine Sales Price (USD/Pcs)
Figure India Premenstrual Syndrome Medicine Sales Market Share
Table Global E Premenstrual Syndrome Medicine Sales (K Pcs) by Type
Table Different Types Premenstrual Syndrome Medicine Product Interview Price
Table Global E Premenstrual Syndrome Medicine Sales (K Pcs) by Application
Table Different Application Premenstrual Syndrome Medicine Product Interview Price
Table Asarina Pharma AB Information List
Table Product Overview
Table Asarina Pharma AB Premenstrual Syndrome Medicine Revenue (Million USD), Sales (K Pcs), Ex-factory Price (USD/Pcs)
Figure Asarina Pharma AB Premenstrual Syndrome Medicine Business Region Distribution
Table Pherin Pharmaceuticals Inc Information List
Table Product Overview
Table Pherin Pharmaceuticals Inc Premenstrual Syndrome Medicine Revenue (Million USD), Sales (K Pcs), Ex-factory Price (USD/Pcs)
Figure Pherin Pharmaceuticals Inc Premenstrual Syndrome Medicine Business Region Distribution
Figure Global Premenstrual Syndrome Medicine Market Size (K Pcs) and Growth Rate Forecast
Figure Global Premenstrual Syndrome Medicine Market Size (Million USD) and Growth Rate Forecast
Figure Global Premenstrual Syndrome Medicine Sales Price (USD/Pcs) Forecast
Figure North America Premenstrual Syndrome Medicine Consumption Volume (K Pcs) and Growth Rate Forecast
Figure China Premenstrual Syndrome Medicine Consumption Volume (K Pcs) and Growth Rate Forecast
Figure Europe Premenstrual Syndrome Medicine Consumption Volume (K Pcs) and Growth Rate Forecast
Figure Southeast Asia Premenstrual Syndrome Medicine Consumption Volume (K Pcs) and Growth Rate Forecast
Figure Japan Premenstrual Syndrome Medicine Consumption Volume (K Pcs) and Growth Rate Forecast
Figure India Premenstrual Syndrome Medicine Consumption Volume (K Pcs) and Growth Rate Forecast
Table Global Sales Volume (K Pcs) of Premenstrual Syndrome Medicine by Type
Table Global Consumption Volume (K Pcs) of Premenstrual Syndrome Medicine by Application
Table Traders or Distributors with Contact Information of Premenstrual Syndrome Medicine by Region
Key Market Players
The competitive landscape features specialized biotech companies pioneering novel mechanisms, alongside large pharma with established CNS and women's health portfolios.
-
Pipeline Innovators & Specialized Biotech:
-
Asarina Pharma AB: Developer of sepranolone (ISO-1), a selective GABA-A modulating steroid antagonist (SAMSA) targeting PMDD.
-
Marinus Pharmaceuticals, Inc.: Developer of ganaxolone, a neuroactive steroid GABA-A receptor positive allosteric modulator, with potential in PMDD and other CNS disorders.
-
Fabre-Kramer Pharmaceuticals: Developer of paroxetine mesylate, a low-dose SSRI specifically approved for PMDD in some regions.
-
Pherin Pharmaceuticals Inc.: Early-stage research on pheromone-based therapeutics.
-
-
Large Pharmaceutical Companies with Relevant Portfolios:
-
Pfizer Inc. (Historical and ongoing women's health and CNS research).
-
GlaxoSmithKline plc (GSK) (Holder of paroxetine license; broad CNS portfolio).
-
Eli Lilly and Company (Major player in neuroscience).
-
Bayer AG (Strong presence in women's health, though historically focused on contraception/fertility).
-
Sumitomo Pharma Co., Ltd. (Through its acquisition of Myovant Sciences, with expertise in endocrine therapies).
-
4. Market Segmentation Analysis
4.1 By Drug Class & Mechanism of Action
-
Selective Serotonin Reuptake Inhibitors (SSRIs): First-line pharmacological treatment for PMDD (e.g., fluoxetine, sertraline, paroxetine). Can be used continuously or luteal-phase only.
-
Neurosteroid & GABA-Targeted Therapies (Novel/High-Growth Segment):
-
GABA-A Receptor Modulators: Sepranolone (antagonist) and ganaxolone (PAM) - target allopregnanolone-driven mood symptoms.
-
*5α-Reductase Inhibitors:* E.g., dutasteride - inhibits conversion of progesterone to allopregnanolone; investigational for PMDD.
-
-
Hormonal Suppression Therapies: Includes combined oral contraceptives (COCs), particularly those containing drospirenone, and GnRH agonists (e.g., leuprolide) for severe cases.
-
Symptomatic Relief & Adjuncts: Includes analgesics (NSAIDs), diuretics (spironolactone), and herbal/nutraceutical supplements (Vitex agnus-castus, calcium).
4.2 By Disorder Severity & Indication
-
Premenstrual Dysphoric Disorder (PMDD): The primary target for novel prescription therapies due to its severity and clear diagnostic criteria (DSM-5). Represents the high-value segment.
-
Moderate-to-Severe PMS: Larger patient population, often managed with OTC products, supplements, and lifestyle interventions, but a potential market for new Rx options.
4.3 By Treatment Regimen
-
Continuous Daily Dosing: Standard for SSRIs and hormonal contraceptives.
-
Intermittent (Luteal Phase) Dosing: Unique to PMS/PMDD. Involves taking medication only during the 14-day period before menstruation. A key differentiator for novel agents.
-
As-Needed Symptomatic Relief: For physical symptoms like pain and bloating.
