Global Pyrosequencing Market Strategic Research Report (2025–2036)
Western Market Research predicts that the Global Pyrosequencing Market was valued at USD 1.02 Billion in 2025 and is expected to reach USD 1.95 Billion by the year 2036, growing at a CAGR of 6.1% globally during the forecast period.
1. Global Pyrosequencing Market Overview
Pyrosequencing is a unique "sequencing-by-synthesis" technology based on the detection of released pyrophosphate during DNA synthesis. It provides a real-time, bioluminescent, and quantitative method for DNA analysis. Unlike larger Next-Generation Sequencing (NGS) platforms focused on whole genomes, pyrosequencing has carved a high-value niche in targeted sequencing, specifically for Single Nucleotide Polymorphism (SNP) analysis, epigenetic methylation studies, and clinical microbial identification.
This research highlights the transition of pyrosequencing from a specialized academic tool to a standardized clinical diagnostic asset. The study evaluates the market landscape from 2020–2024 to project growth through 2036, focusing on the integration of microfluidics and the rising demand for liquid biopsies in oncology.
2. Impact of COVID-19 on Pyrosequencing Market
The COVID-19 pandemic served as a catalyst for genomic infrastructure globally. While initial lockdowns delayed non-COVID research, the demand for rapid genetic profiling of viral strains and secondary bacterial infections spiked. Pyrosequencing platforms were specifically utilized for the rapid identification of antibiotic resistance markers in COVID-19 patients suffering from secondary pneumonia. Post-pandemic, the "genomics-first" approach in public health has led to permanent increased funding for pyrosequencing-capable laboratories.
3. Global Pyrosequencing Market Segmentation
By Component (New Segment):
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Instruments: Automated pyrosequencing platforms and dedicated workstations.
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Consumables & Reagents: Highly recurring revenue from enzyme mixes (Luciferase/Apyrase), substrates, and specialized primer kits.
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Software & Services: Data interpretation tools and outsourced sequencing services.
By Technique (New Segment):
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Solid-Phase Pyrosequencing: Utilizes immobilized DNA templates.
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Liquid-Phase Pyrosequencing: Streamlined approach where all reactions occur in a single volume.
By Field of Use (Type):
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Diagnostics: Infectious disease testing and oncology diagnostics.
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Drug Discovery: Identifying genetic targets for small molecule development.
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Epigenetics/Biomarker Discovery: Specifically methylation analysis (the "gold standard" application for pyrosequencing).
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Personalized Medicine: Pharmacogenomics to determine patient-specific drug responses.
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Agriculture & Animal Research: Seed purity testing and livestock breeding markers.
By Application (End-User):
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Research Centers & Academic Institutes
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Hospitals & Diagnostic Clinics
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Pharmaceutical & Biotechnology Companies
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Forensic & Law Enforcement Labs
4. Competitive Landscape: Top Key Players
The market is characterized by a mix of platform providers and specialized service organizations.
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QIAGEN (Germany/Netherlands) – Current market leader via the PyroMark platform.
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Illumina, Inc. (USA)
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Thermo Fisher Scientific (USA)
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Beijing Genomics Institute (BGI) (China)
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Macrogen, Inc. (South Korea)
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Eurofins Genomics (Germany)
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Source BioScience (UK)
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Microsynth AG (Switzerland)
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Takara Bio, Inc. (Japan)
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Genomnia (Italy)
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CeGaT GmbH (Germany)
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Seqomics (Hungary)
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GenScript Biotech (USA/China)
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Azenta Life Sciences (USA)
5. Regional Analysis
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North America: Holds the largest share, driven by a robust oncology research sector and high adoption of personalized medicine in the U.S. and Canada.
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Europe: A key hub for epigenetic research. Countries like Germany and the UK lead in using pyrosequencing for clinical microbiology.
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Asia-Pacific: The fastest-growing region. Rapidly expanding biotech sectors in China, India, and South Korea, coupled with government-funded precision medicine initiatives, are primary drivers.
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South America: Growing interest in agricultural genomics and seed quality control in Brazil and Argentina.
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Middle East & Africa: Increasing adoption in forensic and diagnostic labs in the GCC region.
6. Porter’s Five Forces Analysis
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Threat of New Entrants (Low): High barriers due to extensive patent thickets surrounding bioluminescence-based sequencing.
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Bargaining Power of Buyers (High): Research institutes often have limited budgets and can choose between various sequencing technologies, pressuring manufacturers on pricing.
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Bargaining Power of Suppliers (Medium): Proprietary enzymes and specialized high-purity chemicals are sourced from limited suppliers.
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Threat of Substitutes (High): Alternative NGS (Next-Gen Sequencing) technologies and Sanger sequencing compete for market share in different read-length categories.
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Competitive Rivalry (High): Players are focused on "niche dominance," particularly in the methylation and SNP sectors.
7. SWOT Analysis
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Strengths: Unmatched accuracy in short-read quantitative analysis; superior for DNA methylation studies.
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Weaknesses: Limited read length compared to other NGS methods; high cost of reagents for large-scale runs.
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Opportunities: Growing demand for liquid biopsies; integration with AI for faster result interpretation.
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Threats: Rapid technological obsolescence; competition from low-cost nanopore sequencing.
8. Trend Analysis
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Epigenetic Diagnostics: Shift toward using pyrosequencing for early-stage cancer screening through blood-based methylation markers.
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Automation of Workflows: Development of fully integrated "sample-to-insight" platforms that reduce manual handling.
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Miniaturization: Adoption of microfluidic technologies to reduce reagent consumption and lower the cost per run.
9. Drivers & Challenges
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Drivers:
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Rising global prevalence of chronic diseases requiring targeted genetic testing.
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Increasing use of pharmacogenomics to reduce adverse drug reactions.
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Growth in customized agricultural breeding and GMO testing.
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Challenges:
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Requirement for highly skilled laboratory personnel to interpret bioluminescent data.
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High initial capital investment for small to mid-sized laboratories.
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10. Value Chain Analysis
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Component Sourcing: Specialized enzyme production (Luciferase/Sulfurylase).
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Instrument Assembly: Integration of high-sensitivity light detectors and fluidic systems.
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Distribution: Global network of life science distributors and direct institutional sales.
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Application: Genomic analysis performed in clinical or research settings.
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Data Processing: Bioinformatics software turns bioluminescent signals into genetic code.
11. Quick Recommendations for Stakeholders
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For Manufacturers: Focus on developing low-cost, single-use kits for infectious disease identification to penetrate the diagnostic hospital market.
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For Academic Labs: Prioritize the use of pyrosequencing for validation of high-throughput NGS results, as it remains the gold standard for quantitative accuracy in targeted regions.
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For Investors: Look toward companies with strong IP in methylation-based cancer diagnostics, as this is the most lucrative long-term application for pyrosequencing.
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For Service Providers: Offer specialized epigenetic profiling services, which require more technical expertise than standard genomic sequencing.
1. Market Overview of Pyrosequencing
1.1 Pyrosequencing Market Overview
1.1.1 Pyrosequencing Product Scope
1.1.2 Market Status and Outlook
1.2 Pyrosequencing Market Size by Regions: 2015 VS 2021 VS 2026
1.3 Pyrosequencing Historic Market Size by Regions
1.4 Pyrosequencing Forecasted Market Size by Regions
1.5 Covid-19 Impact on Key Regions, Keyword Market Size YoY Growth
1.5.1 North America
1.5.2 East Asia
1.5.3 Europe
1.5.4 South Asia
1.5.5 Southeast Asia
1.5.6 Middle East
1.5.7 Africa
1.5.8 Oceania
1.5.9 South America
1.5.10 Rest of the World
1.6 Coronavirus Disease 2019 (Covid-19) Impact Will Have a Severe Impact on Global Growth
1.6.1 Covid-19 Impact: Global GDP Growth, 2019, 2020 and 2021 Projections
1.6.2 Covid-19 Impact: Commodity Prices Indices
1.6.3 Covid-19 Impact: Global Major Government Policy
2. Covid-19 Impact Pyrosequencing Sales Market by Type
2.1 Global Pyrosequencing Historic Market Size by Type
2.2 Global Pyrosequencing Forecasted Market Size by Type
2.3 Diagnostics
2.4 Drug Discovery
2.5 Biomarker Discovery
2.6 Personalized Medicine
2.7 Agriculture and Animal Research
2.8 Others
3. Covid-19 Impact Pyrosequencing Sales Market by Application
3.1 Global Pyrosequencing Historic Market Size by Application
3.2 Global Pyrosequencing Forecasted Market Size by Application
3.3 Research Centers & Academic/Government Institutes
3.4 Hospitals & Clinics
3.5 Pharmaceutical & Biotechnology Companies
3.6 Others
4. Covid-19 Impact Market Competition by Manufacturers
4.1 Global Pyrosequencing Production Capacity Market Share by Manufacturers
4.2 Global Pyrosequencing Revenue Market Share by Manufacturers
4.3 Global Pyrosequencing Average Price by Manufacturers
5. Company Profiles and Key Figures in Pyrosequencing Business
5.1 Beijing Genomics Institute (BGI)
5.1.1 Beijing Genomics Institute (BGI) Company Profile
5.1.2 Beijing Genomics Institute (BGI) Pyrosequencing Product Specification
5.1.3 Beijing Genomics Institute (BGI) Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
5.2 Cegat (Centre for Genomics and Transcriptomics)
5.2.1 Cegat (Centre for Genomics and Transcriptomics) Company Profile
5.2.2 Cegat (Centre for Genomics and Transcriptomics) Pyrosequencing Product Specification
5.2.3 Cegat (Centre for Genomics and Transcriptomics) Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
5.3 Eurofins Genomics
5.3.1 Eurofins Genomics Company Profile
5.3.2 Eurofins Genomics Pyrosequencing Product Specification
5.3.3 Eurofins Genomics Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
5.4 Febit / Comprehensive Biomarker Center (CBC)
5.4.1 Febit / Comprehensive Biomarker Center (CBC) Company Profile
5.4.2 Febit / Comprehensive Biomarker Center (CBC) Pyrosequencing Product Specification
5.4.3 Febit / Comprehensive Biomarker Center (CBC) Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
5.5 Genomnia
5.5.1 Genomnia Company Profile
5.5.2 Genomnia Pyrosequencing Product Specification
5.5.3 Genomnia Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
5.6 Illumina
5.6.1 Illumina Company Profile
5.6.2 Illumina Pyrosequencing Product Specification
5.6.3 Illumina Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
5.7 Macrogen
5.7.1 Macrogen Company Profile
5.7.2 Macrogen Pyrosequencing Product Specification
5.7.3 Macrogen Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
5.8 Microsynth AG
5.8.1 Microsynth AG Company Profile
5.8.2 Microsynth AG Pyrosequencing Product Specification
5.8.3 Microsynth AG Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
5.9 Seqomics
5.9.1 Seqomics Company Profile
5.9.2 Seqomics Pyrosequencing Product Specification
5.9.3 Seqomics Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
5.10 Source Bio Science
5.10.1 Source Bio Science Company Profile
5.10.2 Source Bio Science Pyrosequencing Product Specification
5.10.3 Source Bio Science Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
5.11 Pyrosequencing AB
5.11.1 Pyrosequencing AB Company Profile
5.11.2 Pyrosequencing AB Pyrosequencing Product Specification
5.11.3 Pyrosequencing AB Pyrosequencing Production Capacity, Revenue, Price and Gross Margin
6. North America
6.1 North America Pyrosequencing Market Size
6.2 North America Pyrosequencing Key Players in North America
6.3 North America Pyrosequencing Market Size by Type
6.4 North America Pyrosequencing Market Size by Application
7. East Asia
7.1 East Asia Pyrosequencing Market Size
7.2 East Asia Pyrosequencing Key Players in North America
7.3 East Asia Pyrosequencing Market Size by Type
7.4 East Asia Pyrosequencing Market Size by Application
8. Europe
8.1 Europe Pyrosequencing Market Size
8.2 Europe Pyrosequencing Key Players in North America
8.3 Europe Pyrosequencing Market Size by Type
8.4 Europe Pyrosequencing Market Size by Application
9. South Asia
9.1 South Asia Pyrosequencing Market Size
9.2 South Asia Pyrosequencing Key Players in North America
9.3 South Asia Pyrosequencing Market Size by Type
9.4 South Asia Pyrosequencing Market Size by Application
10. Southeast Asia
10.1 Southeast Asia Pyrosequencing Market Size
10.2 Southeast Asia Pyrosequencing Key Players in North America
10.3 Southeast Asia Pyrosequencing Market Size by Type
10.4 Southeast Asia Pyrosequencing Market Size by Application
11. Middle East
11.1 Middle East Pyrosequencing Market Size
11.2 Middle East Pyrosequencing Key Players in North America
11.3 Middle East Pyrosequencing Market Size by Type
11.4 Middle East Pyrosequencing Market Size by Application
12. Africa
12.1 Africa Pyrosequencing Market Size
12.2 Africa Pyrosequencing Key Players in North America
12.3 Africa Pyrosequencing Market Size by Type
12.4 Africa Pyrosequencing Market Size by Application
13. Oceania
13.1 Oceania Pyrosequencing Market Size
13.2 Oceania Pyrosequencing Key Players in North America
13.3 Oceania Pyrosequencing Market Size by Type
13.4 Oceania Pyrosequencing Market Size by Application
14. South America
14.1 South America Pyrosequencing Market Size
14.2 South America Pyrosequencing Key Players in North America
14.3 South America Pyrosequencing Market Size by Type
14.4 South America Pyrosequencing Market Size by Application
15. Rest of the World
15.1 Rest of the World Pyrosequencing Market Size
15.2 Rest of the World Pyrosequencing Key Players in North America
15.3 Rest of the World Pyrosequencing Market Size by Type
15.4 Rest of the World Pyrosequencing Market Size by Application
16 Pyrosequencing Market Dynamics
16.1 Covid-19 Impact Market Top Trends
16.2 Covid-19 Impact Market Drivers
16.3 Covid-19 Impact Market Challenges
16.4 Porter
Global Pyrosequencing Market Segmentation
By Component (New Segment):
-
Instruments: Automated pyrosequencing platforms and dedicated workstations.
-
Consumables & Reagents: Highly recurring revenue from enzyme mixes (Luciferase/Apyrase), substrates, and specialized primer kits.
-
Software & Services: Data interpretation tools and outsourced sequencing services.
By Technique (New Segment):
-
Solid-Phase Pyrosequencing: Utilizes immobilized DNA templates.
-
Liquid-Phase Pyrosequencing: Streamlined approach where all reactions occur in a single volume.
By Field of Use (Type):
-
Diagnostics: Infectious disease testing and oncology diagnostics.
-
Drug Discovery: Identifying genetic targets for small molecule development.
-
Epigenetics/Biomarker Discovery: Specifically methylation analysis (the "gold standard" application for pyrosequencing).
-
Personalized Medicine: Pharmacogenomics to determine patient-specific drug responses.
-
Agriculture & Animal Research: Seed purity testing and livestock breeding markers.
By Application (End-User):
-
Research Centers & Academic Institutes
-
Hospitals & Diagnostic Clinics
-
Pharmaceutical & Biotechnology Companies
-
Forensic & Law Enforcement Labs
4. Competitive Landscape: Top Key Players
The market is characterized by a mix of platform providers and specialized service organizations.
-
QIAGEN (Germany/Netherlands) – Current market leader via the PyroMark platform.
-
Illumina, Inc. (USA)
-
Thermo Fisher Scientific (USA)
-
Beijing Genomics Institute (BGI) (China)
-
Macrogen, Inc. (South Korea)
-
Eurofins Genomics (Germany)
-
Source BioScience (UK)
-
Microsynth AG (Switzerland)
