Global Mixed-mode Chromatography Resin Market Overview (2026–2036)
Western Market Research predicts that the Mixed-mode Chromatography Resin Market was valued at USD xxxx units in 2025 and is expected to reach USD xxxx units by 2036, expanding at a CAGR of xx% over the forecast period. Mixed-mode chromatography resins combine multiple interaction mechanisms—such as ionic, hydrophobic, hydrogen bonding, and metal affinity—within a single ligand system, enabling higher selectivity and resolution during biomolecule purification.
The market is experiencing strong growth driven by the rapid expansion of biopharmaceutical manufacturing, increasing demand for monoclonal antibodies, and the rising complexity of biologic drug pipelines. Mixed-mode resins are increasingly adopted as process intensification tools, reducing purification steps, improving yield, and lowering overall production costs.
Market Description
Mixed-mode chromatography resin represents a critical advancement in downstream bioprocessing technologies. Unlike traditional single-mode chromatography, mixed-mode resins provide multiple interaction points with target biomolecules, allowing enhanced separation of closely related impurities such as aggregates, host cell proteins, and charge variants.
These resins are widely used in polishing and capture steps for complex biologics, particularly where conventional ion-exchange or affinity chromatography fails to deliver sufficient resolution. Their robustness across wide pH and conductivity ranges makes them highly suitable for large-scale biomanufacturing.
The increasing focus on biosimilars, next-generation antibodies, and recombinant proteins has accelerated the adoption of mixed-mode chromatography solutions across both clinical and commercial manufacturing stages.
Impact of COVID-19 on the Mixed-mode Chromatography Resin Market
The COVID-19 pandemic had a mixed impact on the market in 2020. Initial supply-chain disruptions and laboratory shutdowns temporarily slowed non-COVID-related research activities. However, demand rapidly rebounded due to the unprecedented surge in vaccine, antibody, and therapeutic protein development.
Biopharmaceutical manufacturers increased investments in scalable and efficient purification technologies, significantly benefiting mixed-mode chromatography resin adoption. Post-pandemic, the market has remained resilient, supported by sustained R&D funding, biologics pipeline expansion, and manufacturing capacity scaling.
Global Mixed-mode Chromatography Resin Market Segmentation
By Type
-
Ion Exchange–Hydrophobic Type
Combines ionic and hydrophobic interactions, widely used for impurity removal and polishing of complex protein mixtures. -
Hydroxyapatite Type
Utilizes calcium phosphate–based interactions, effective for separating proteins based on charge and affinity differences.
By Application
-
Monoclonal Antibodies
Dominant application segment due to extensive use in therapeutic and biosimilar production. -
Non-antibody Protein
Includes enzymes, growth factors, and recombinant proteins used in diagnostics and therapeutics. -
Polyclonal Antibodies
Used in plasma-derived products and specialized immunotherapies.
Regional Analysis
-
North America
Market leadership driven by strong biopharmaceutical infrastructure, R&D investment, and regulatory maturity. -
Europe
Growth supported by biosimilar development, academic research, and contract manufacturing expansion. -
Asia-Pacific
Fastest-growing region due to increasing biologics manufacturing in China, India, and South Korea. -
South America
Moderate growth driven by expanding pharmaceutical manufacturing capabilities. -
Middle East & Africa
Emerging demand supported by healthcare infrastructure development and regional biotech initiatives.
Top Key Players in the Mixed-mode Chromatography Resin Market
-
Pall Corporation
Provides advanced chromatography resins and integrated downstream processing solutions. -
GE Healthcare
A major innovator in chromatography resins, offering high-performance mixed-mode platforms for biologics purification. -
Bio-Rad Laboratories
Supplies chromatography media for research, process development, and pilot-scale applications. -
Tosoh Corporation
Known for high-quality hydroxyapatite and specialty chromatography resins. -
Merck
Delivers premium chromatography resins through its life science portfolio, supporting large-scale biologics manufacturing.
DROT Analysis
Drivers
-
Rapid growth of monoclonal antibody and biologics pipelines
-
Need for high-resolution and multifunctional purification technologies
-
Increasing adoption of process intensification strategies
Restraints
-
High cost of advanced chromatography resins
-
Complex method development and optimization requirements
Opportunities
-
Rising demand for biosimilars and next-generation biologics
-
Expansion of contract development and manufacturing organizations
-
Technological advancements in ligand chemistry and resin stability
Threats
-
Competition from alternative purification technologies
-
Stringent regulatory requirements for bioprocess validation
Value Chain Analysis
The mixed-mode chromatography resin value chain begins with raw material suppliers, providing polymer matrices, ligands, and functional chemicals. These inputs are utilized by resin manufacturers, who design, functionalize, and validate chromatography media. The resins are then supplied to biopharmaceutical companies, CROs, and CDMOs, where they are used in downstream purification workflows. Final outputs include purified biologics such as antibodies and recombinant proteins delivered to clinical, commercial, and diagnostic end users.
Market Outlook
The global mixed-mode chromatography resin market is expected to witness robust growth through 2036, driven by continued expansion of the biopharmaceutical sector and increasing complexity of biologic molecules. Mixed-mode resins will play a critical role in next-generation purification processes by enabling higher efficiency, reduced processing steps, and improved product quality.
Asia-Pacific is anticipated to emerge as a key growth engine, while North America and Europe will continue to dominate innovation and high-value applications. Companies focusing on scalable, regulatory-compliant, and application-specific resin solutions are expected to strengthen their competitive position in the evolving global landscape.
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1. Market Overview of Mixed-mode Chromatography Resin
1.1 Mixed-mode Chromatography Resin Market Overview
1.1.1 Mixed-mode Chromatography Resin Product Scope
1.1.2 Market Status and Outlook
1.2 Mixed-mode Chromatography Resin Market Size by Regions:
1.3 Mixed-mode Chromatography Resin Historic Market Size by Regions
1.4 Mixed-mode Chromatography Resin Forecasted Market Size by Regions
1.5 Covid-19 Impact on Key Regions, Keyword Market Size YoY Growth
1.5.1 North America
1.5.2 East Asia
1.5.3 Europe
1.5.4 South Asia
1.5.5 Southeast Asia
1.5.6 Middle East
1.5.7 Africa
1.5.8 Oceania
1.5.9 South America
1.5.10 Rest of the World
1.6 Coronavirus Disease 2019 (Covid-19) Impact Will Have a Severe Impact on Global Growth
1.6.1 Covid-19 Impact: Global GDP Growth, 2019, 2020 and 2021 Projections
1.6.2 Covid-19 Impact: Commodity Prices Indices
1.6.3 Covid-19 Impact: Global Major Government Policy
2. Covid-19 Impact Mixed-mode Chromatography Resin Sales Market by Type
2.1 Global Mixed-mode Chromatography Resin Historic Market Size by Type
2.2 Global Mixed-mode Chromatography Resin Forecasted Market Size by Type
2.3 Ion Exchange-Hydrophobic Type
2.4 Hydroxyapatite Type
3. Covid-19 Impact Mixed-mode Chromatography Resin Sales Market by Application
3.1 Global Mixed-mode Chromatography Resin Historic Market Size by Application
3.2 Global Mixed-mode Chromatography Resin Forecasted Market Size by Application
3.3 Monoclonal Antibodies
3.4 Non-antibody Protein
3.5 Polyclonal Antibodies
4. Covid-19 Impact Market Competition by Manufacturers
4.1 Global Mixed-mode Chromatography Resin Production Capacity Market Share by Manufacturers
4.2 Global Mixed-mode Chromatography Resin Revenue Market Share by Manufacturers
4.3 Global Mixed-mode Chromatography Resin Average Price by Manufacturers
5. Company Profiles and Key Figures in Mixed-mode Chromatography Resin Business
5.1 Pall Corporation
5.1.1 Pall Corporation Company Profile
5.1.2 Pall Corporation Mixed-mode Chromatography Resin Product Specification
5.1.3 Pall Corporation Mixed-mode Chromatography Resin Production Capacity, Revenue, Price and Gross Margin
5.2 GE Healthcare
5.2.1 GE Healthcare Company Profile
5.2.2 GE Healthcare Mixed-mode Chromatography Resin Product Specification
5.2.3 GE Healthcare Mixed-mode Chromatography Resin Production Capacity, Revenue, Price and Gross Margin
5.3 Bio-Rad Laboratories
5.3.1 Bio-Rad Laboratories Company Profile
5.3.2 Bio-Rad Laboratories Mixed-mode Chromatography Resin Product Specification
5.3.3 Bio-Rad Laboratories Mixed-mode Chromatography Resin Production Capacity, Revenue, Price and Gross Margin
5.4 Tosoh Corporation
5.4.1 Tosoh Corporation Company Profile
5.4.2 Tosoh Corporation Mixed-mode Chromatography Resin Product Specification
5.4.3 Tosoh Corporation Mixed-mode Chromatography Resin Production Capacity, Revenue, Price and Gross Margin
5.5 Merck
5.5.1 Merck Company Profile
5.5.2 Merck Mixed-mode Chromatography Resin Product Specification
5.5.3 Merck Mixed-mode Chromatography Resin Production Capacity, Revenue, Price and Gross Margin
6. North America
6.1 North America Mixed-mode Chromatography Resin Market Size
6.2 North America Mixed-mode Chromatography Resin Key Players in North America
6.3 North America Mixed-mode Chromatography Resin Market Size by Type
6.4 North America Mixed-mode Chromatography Resin Market Size by Application
7. East Asia
7.1 East Asia Mixed-mode Chromatography Resin Market Size
7.2 East Asia Mixed-mode Chromatography Resin Key Players in North America
7.3 East Asia Mixed-mode Chromatography Resin Market Size by Type
7.4 East Asia Mixed-mode Chromatography Resin Market Size by Application
8. Europe
8.1 Europe Mixed-mode Chromatography Resin Market Size
8.2 Europe Mixed-mode Chromatography Resin Key Players in North America
8.3 Europe Mixed-mode Chromatography Resin Market Size by Type
8.4 Europe Mixed-mode Chromatography Resin Market Size by Application
9. South Asia
9.1 South Asia Mixed-mode Chromatography Resin Market Size
9.2 South Asia Mixed-mode Chromatography Resin Key Players in North America
9.3 South Asia Mixed-mode Chromatography Resin Market Size by Type
9.4 South Asia Mixed-mode Chromatography Resin Market Size by Application
10. Southeast Asia
10.1 Southeast Asia Mixed-mode Chromatography Resin Market Size
10.2 Southeast Asia Mixed-mode Chromatography Resin Key Players in North America
10.3 Southeast Asia Mixed-mode Chromatography Resin Market Size by Type
10.4 Southeast Asia Mixed-mode Chromatography Resin Market Size by Application
11. Middle East
11.1 Middle East Mixed-mode Chromatography Resin Market Size
11.2 Middle East Mixed-mode Chromatography Resin Key Players in North America
11.3 Middle East Mixed-mode Chromatography Resin Market Size by Type
11.4 Middle East Mixed-mode Chromatography Resin Market Size by Application
12. Africa
12.1 Africa Mixed-mode Chromatography Resin Market Size
12.2 Africa Mixed-mode Chromatography Resin Key Players in North America
12.3 Africa Mixed-mode Chromatography Resin Market Size by Type
12.4 Africa Mixed-mode Chromatography Resin Market Size by Application
13. Oceania
13.1 Oceania Mixed-mode Chromatography Resin Market Size
13.2 Oceania Mixed-mode Chromatography Resin Key Players in North America
13.3 Oceania Mixed-mode Chromatography Resin Market Size by Type
13.4 Oceania Mixed-mode Chromatography Resin Market Size by Application
14. South America
14.1 South America Mixed-mode Chromatography Resin Market Size
14.2 South America Mixed-mode Chromatography Resin Key Players in North America
14.3 South America Mixed-mode Chromatography Resin Market Size by Type
14.4 South America Mixed-mode Chromatography Resin Market Size by Application
15. Rest of the World
15.1 Rest of the World Mixed-mode Chromatography Resin Market Size
15.2 Rest of the World Mixed-mode Chromatography Resin Key Players in North America
15.3 Rest of the World Mixed-mode Chromatography Resin Market Size by Type
15.4 Rest of the World Mixed-mode Chromatography Resin Market Size by Application
16 Mixed-mode Chromatography Resin Market Dynamics
16.1 Covid-19 Impact Market Top Trends
16.2 Covid-19 Impact Market Drivers
16.3 Covid-19 Impact Market Challenges
16.4 Porter
Global Mixed-mode Chromatography Resin Market Segmentation
By Type
-
Ion Exchange–Hydrophobic Type
Combines ionic and hydrophobic interactions, widely used for impurity removal and polishing of complex protein mixtures. -
Hydroxyapatite Type
Utilizes calcium phosphate–based interactions, effective for separating proteins based on charge and affinity differences.
By Application
-
Monoclonal Antibodies
Dominant application segment due to extensive use in therapeutic and biosimilar production. -
Non-antibody Protein
Includes enzymes, growth factors, and recombinant proteins used in diagnostics and therapeutics. -
Polyclonal Antibodies
Used in plasma-derived products and specialized immunotherapies.
Regional Analysis
-
North America
Market leadership driven by strong biopharmaceutical infrastructure, R&D investment, and regulatory maturity. -
Europe
Growth supported by biosimilar development, academic research, and contract manufacturing expansion. -
Asia-Pacific
Fastest-growing region due to increasing biologics manufacturing in China, India, and South Korea. -
South America
Moderate growth driven by expanding pharmaceutical manufacturing capabilities. -
Middle East & Africa
Emerging demand supported by healthcare infrastructure development and regional biotech initiatives.
Top Key Players in the Mixed-mode Chromatography Resin Market
-
Pall Corporation
Provides advanced chromatography resins and integrated downstream processing solutions. -
GE Healthcare
A major innovator in chromatography resins, offering high-performance mixed-mode platforms for biologics purification. -
Bio-Rad Laboratories
Supplies chromatography media for research, process development, and pilot-scale applications. -
Tosoh Corporation
Known for high-quality hydroxyapatite and specialty chromatography resins. -
Merck
Delivers premium chromatography resins through its life science portfolio, supporting large-scale biologics manufacturing.
